Earliest functional declines in Huntington disease
نویسندگان
چکیده
منابع مشابه
Cognitive Declines Precede and Predict Functional Declines in Aging and Alzheimer’s Disease
OBJECTIVE To investigate the temporal ordering of cognitive and functional declines separately in older adults with or without Alzheimer's disease (AD). DESIGN AND SETTING A community-based longitudinal study of aging and dementia in Northern Manhattan (Washington Heights/Hamilton Heights Inwood Columbia Aging Project) and a multicenter, clinic-based longitudinal study of prevalent AD at Colu...
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There have been extraordinary advances in our knowledge of the underlying gene, the protein it encodes, various models of disease, and potential targets for effective therapies for Huntington disease. Huntington disease research has increased exponentially in the past 25 years, and we now understand many of the molecular mechanisms underlying the disease. Still, more work needs to be done befor...
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Functional limitation (difficulty in walking, difficulty in bending, paralysis, blindness in at least one eye, and deafness in at least one ear) in the United States has fallen at an average annual rate of 0.6% among men age 50 to 74 from the early twentieth century to the early 1990s. 24% of this decline is attributable to reductions in the debilitating effects of chronic conditions, 37% to re...
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OBJECTIVE The objective was to review the major differences of Huntington disease (HD) in Asian population from those in the Caucasian population. DATA SOURCES Data cited in this review were obtained from PubMed database and China National Knowledge Infrastructure (CNKI) from 1994 to 2014. All the papers were written in English or Chinese languages, with the terms of Asia/Asian, HD, genotype,...
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The Functional Rating Scale Taskforce for pre-Huntington Disease (FuRST-pHD) is a multinational, multidisciplinary initiative with the goal of developing a data-driven, comprehensive, psychometrically sound, rating scale for assessing symptoms and functional ability in prodromal and early Huntington disease (HD) gene expansion carriers. The process involves input from numerous sources to identi...
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ژورنال
عنوان ژورنال: Psychiatry Research
سال: 2010
ISSN: 0165-1781
DOI: 10.1016/j.psychres.2010.04.030